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  1. For example, in the P024 neoadjuvant trial of letrozole versus tamoxifen 23, a small number of ER negative tumours protocol violators were entered into the study and none responded to either drug early signs of pregnancy after clomid For women who delay RRM, a diagnosis of estrogen positive or negative breast cancer, even if detected early, requires fertility preservation and delay in pregnancy due, for example, to prolonged hormonal therapy

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